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原料药及中间体
 
抗肿瘤药物
 
 
抗糖尿病药物
 
 
消化系统类药物
 
 
免疫类
 
 
活性分子
 
小分子化合物
 
 
PD0166285
 
【别名】
【CAS号】 185039-89-8
【目录编号】 1711012
【纯度】 98%
【分子式】 C26H27Cl2N5O2
【分子量】 512.43
【简介】 PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.
 
 
  详细介绍
   
PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.PD0166285 is identified to inhibit Wee1 activity at nanomolar concentrations. The inhibitor abrogates G2/M checkpoint inducing early cell division. At the cellular level, 0.5 μM PD0166285 dramatically inhibits irradiation-induced Cdc2 phosphorylation at the Tyr-15 and Thr-14 in seven of seven cancer cell lines tested. This G2 checkpoint abrogation by PD0166285 is demonstrated to kill cancer cells. PD0166285 does not inhibit Cdc2/cyclin B but inhibits Chk1 kinase at a much higher concentration (3433 nM). the treatment of cells with the inhibitor is related to microtubule stabilization and decrease in cyclin D transcription. Thus, PD0166285 may be a potentially useful anti-cancer therapy
 
 
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